Little Known Facts About ceesdekker.
Little Known Facts About ceesdekker.
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Employing single-molecule optical and AFM imaging and pressure-spectroscopy techniques, we seek out to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigation interests include:
Human Rad51 filaments on double- and one-stranded DNA: correlating common and irregular varieties with recombination function.
Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins
Considering that 2000, Dekker has shifted the main target of his get the job done towards biophysics in which he scientific tests the properties of single biomolecules and cells using the equipment of nanotechnology. This alteration of discipline was pushed by his fascination with the remarkable working of biological molecular constructions, together with via the lengthy-phrase viewpoint a large number of attention-grabbing discoveries can be expected On this discipline.[five] Recent strains of exploration in his biophysics group are within the areas of:[6]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time examine from the dynamics DNA supercoils and the invention of supercoil hopping
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
You are a Christian. If you could potentially make this type of synthetic cell, would you be 1 action closer to God, or would the job of God have diminished fairly again?
Circulation-pushed rotary motors which include windmills and h2o wheels drive functional procedures in human Modern society. Whilst samples of such rotary motors also characteristic prominently in cell biology, their synthetic building with the nanoscale has remained hard. In this article we reveal flow-pushed rotary movement of the self-structured DNA nanostructure that may be docked on to a nanopore in a skinny solid-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation upon phoretic docking onto the strong-state nanopore, and subsequently displays a sustained unidirectional rotary motion of up to twenty rev s−one.
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Bulk-area coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro
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Many new phenomena have been discovered, and he and his exploration group founded a leading place During this discipline of study. Dekker and his investigate team learned new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they had been the initial to build a transistor determined by just one cees dekker nanotube molecule.
By way of example, we consider the nucleopore elaborate, a gateway concerning the mobile nucleus and also the cytoplasm. This is an extremely complex procedure and thus challenging to review in a mobile, so we use biomimetics. We reconstruct holes then insert personal features with the nucleopore complicated to check transport as a result of it at the single-molecule level.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style and design in 2005. (nl)